› 6ih0

X-ray diffraction
1.21Å resolution

Aquifex aeolicus LpxC complex with ACHN-975

Released:
DOI: 10.2210/pdb6ih0/pdb
PDB entry 6ih0 coloured by chain, front view.
PDB entry 6ih0 coloured by chain, side view.
PDB entry 6ih0 coloured by chain, top view.
Source organism: Aquifex aeolicus VF5
Entry authors: Li DY, Fan S, Jin YY, Zhang C, Lv GX, Wu GT, Yang ZY

Function and Biology Details

Reaction catalysed: 
UDP-3-O-((3R)-3-hydroxyacyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxyacyl)-alpha-D-glucosamine + acetate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130526 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-3-O-acyl-N-acetylglucosamine deacetylase Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.06 KDa
Source organism: Aquifex aeolicus VF5
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: O67648 (Residues: 1-271; Coverage: 96%)
Gene names: aq_1772, envA, lpxC
Sequence domains: UDP-3-O-acyl N-acetylglycosamine deacetylase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand A5F 1 x A5F
Ligand ZN 1 x ZN
Ligand A5U 1 x A5U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P61
Unit cell:
a: 65.569Å b: 65.569Å c: 131.595Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.164 0.182
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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