› 6iew

X-ray diffraction
1.5Å resolution

The crystal structure of the dNxf2 UBA domain in complex with Panoramix

Released:
DOI: 10.2210/pdb6iew/pdb
PDB entry 6iew coloured by chain, front view.
PDB entry 6iew coloured by chain, side view.
PDB entry 6iew coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.
Zhao K, Cheng S, Miao N, Xu P, Lu X, Zhang Y, Wang M, Ouyang X, Yuan X, Liu W, Lu X, Zhou P, Gu J, Zhang Y, Qiu D, Jin Z, Su C, Peng C, Wang JH, Dong MQ, Wan Y, Ma J, Cheng H, Huang Y, Yu Y
Nat Cell Biol 21 1261-1272 (2019)
PMID: 31570835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194315 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear RNA export factor 2; Protein panoramix Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.25 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9W2H9 (Residues: 249-249, 315-341; Coverage: 5%)
  • Canonical: Q9VV73 (Residues: 789-841; Coverage: 6%)
Gene names: CG4118, CG9754, Panx, nxf2
Sequence domains: TAP C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Unit cell:
a: 29.074Å b: 40.925Å c: 83.091Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.173
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The piRNA pathway in Drosophila ovarian germ and somatic cells.
Sato et al. (2020)
7 more