› 6i80

X-ray diffraction
1.14Å resolution

Crystal Structure of the second bromodomain of BRD2 in complex with RT53

Released:
DOI: 10.2210/pdb6i80/pdb
PDB entry 6i80 coloured by chain, front view.
PDB entry 6i80 coloured by chain, side view.
PDB entry 6i80 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Picaud S, Traquete R, Bernardes GJL, Newman J, Arrowsmith CH, Edwards AM, Bountra C, Filippakopoulos P, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 348-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand H7B 2 x H7B
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2221
Unit cell:
a: 64.409Å b: 66.72Å c: 129.613Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.131 0.143
Expression system: Escherichia coli BL21(DE3)

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