› 6hhf

X-ray diffraction
2.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-alpha serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 51.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31749 (Residues: 2-446; Coverage: 93%)
Gene names: AKT1, PKB, RAC
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand G4K 1 x G4K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 64.37Å b: 68.44Å c: 102.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.274
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?
Martorana et al. (2021)
8 more

23 mentions without citation

Potential of Curcumin in Skin Disorders.
Vollono et al. (2019)
22 more