› 6gvx

X-ray diffraction
2.24Å resolution

Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C)

Released:
DOI: 10.2210/pdb6gvx/pdb
PDB entry 6gvx coloured by chain, front view.
PDB entry 6gvx coloured by chain, side view.
PDB entry 6gvx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).
Rembacz KP, Zrubek KM, Golik P, Michalik K, Bogusz J, Wladyka B, Romanowska M, Dubin G
Arch Biochem Biophys 671 1-7 (2019)
PMID: 31108049

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maternal embryonic leucine zipper kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 39.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14680 (Residues: 1-340; Coverage: 52%)
Gene names: KIAA0175, MELK
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand TAK 2 x TAK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 65.475Å b: 80.074Å c: 77.975Å
α: 90° β: 110.58° γ: 90°
R-values:
R R work R free
0.205 0.203 0.24
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis.
Hu et al. (2022)

2 mentions without citation

EMBER-Embedding Multiple Molecular Fingerprints for Virtual Screening.
Mendolia et al. (2022)
1 more