› 6fvj

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reactions catalysed: 
An acetic ester + H(2)O = an alcohol + acetate
Palmitoyl-CoA + H(2)O = CoA + palmitate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioesterase TesA Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 261 amino acids
Theoretical weight: 29.19 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQD5 (Residues: 1-261; Coverage: 100%)
Gene names: MTCY338.17, Rv2928, tesA
Sequence domains: Thioesterase domain

Ligands and Environments

3 bound ligands:
Ligand E9H 8 x E9H
Ligand MPD 12 x MPD
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2221
Unit cell:
a: 79.07Å b: 224.58Å c: 222.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.236 0.259
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds.
Spilling CD. (2019)
4 other articles

2 mentions without citation

Thioesterase enzyme families: Functions, structures, and mechanisms.
Caswell et al. (2022)
1 more