› 6elm

X-ray diffraction
1.14Å resolution

Crystal structure of the human WNK2 CCT1 domain

Released:
DOI: 10.2210/pdb6elm/pdb
PDB entry 6elm coloured by chain, front view.
PDB entry 6elm coloured by chain, side view.
PDB entry 6elm coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pinkas DM, Bufton JC, Newman JA, Chalk R, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195218 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK2 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3S1 (Residues: 454-549; Coverage: 4%)
Gene names: KIAA1760, P/OKcl.13, PRKWNK2, SDCCAG43, WNK2
Sequence domains: Oxidative-stress-responsive kinase 1 C-terminal domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 28.197Å b: 46.492Å c: 71.296Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.14 0.138 0.168
Expression system: Escherichia coli BL21(DE3)

Quick links