› 6ebv

X-ray diffraction
3Å resolution

Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N7-Pan

Released:
DOI: 10.2210/pdb6ebv/pdb
PDB entry 6ebv coloured by chain, front view.
PDB entry 6ebv coloured by chain, side view.
PDB entry 6ebv coloured by chain, top view.
Source organism: Staphylococcus aureus
Entry authors: Chen Y, Antoshchenko T, Strauss E, Barnard L, Huang YH, Park H

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type II pantothenate kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 267 amino acids
Theoretical weight: 29.13 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FWC7 (Residues: 1-267; Coverage: 100%)
Gene names: SAOUHSC_02371, coaA, coaW
Sequence domains: Fumble

Ligands and Environments

2 bound ligands:
Ligand ADP 4 x ADP
Ligand 27Q 4 x 27Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 72.8Å b: 56.72Å c: 133.62Å
α: 90° β: 99.81° γ: 90°
R-values:
R R work R free
0.231 0.228 0.28
Expression system: Escherichia coli

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