› 6e0g

Electron Microscopy
2.9Å resolution

Mitochondrial peroxiredoxin from Leishmania infantum after heat stress without unfolding client protein

Released:
DOI: 10.2210/pdb6e0g/pdb
PDB entry 6e0g coloured by chain, front view.
PDB entry 6e0g coloured by chain, side view.
PDB entry 6e0g coloured by chain, top view.
Source organism: Leishmania infantum
Primary publication:
Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U
Nat Commun 10 659 (2019)
PMID: 30737390
Related structures: EMD-8947

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-dependent peroxiredoxin Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 226 amino acids
Theoretical weight: 25.4 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A6L0XFC6 (Residues: 1-226; Coverage: 100%)
Gene names: LINJ_23_0050, mTXNPx, tryparedoxin peroxidase
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-8947
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation.
Park et al. (2019)
5 more