› 6db0

X-ray diffraction
1.7Å resolution

N-Terminal bromodomain of Human BRD2 with a Tetrahydroquinoline analogue

Released:
DOI: 10.2210/pdb6db0/pdb
PDB entry 6db0 coloured by chain, front view.
PDB entry 6db0 coloured by chain, side view.
PDB entry 6db0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: White SW, Yun M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150468 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 138 amino acids
Theoretical weight: 16.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25440 (Residues: 67-200; Coverage: 17%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand G3J 2 x G3J
Ligand EPE 1 x EPE
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 114.316Å b: 55.796Å c: 68.363Å
α: 90° β: 94.58° γ: 90°
R-values:
R R work R free
0.165 0.164 0.188
Expression system: Escherichia coli BL21(DE3)

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