› 6ctc

X-ray diffraction
2.6Å resolution

Crystal structure of human transferrin bound to Triferic FPC iron pyrophosphate

Released:
DOI: 10.2210/pdb6ctc/pdb
PDB entry 6ctc coloured by chain, front view.
PDB entry 6ctc coloured by chain, side view.
PDB entry 6ctc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ferric pyrophosphate citrate: interactions with transferrin.
Pratt R, Handelman GJ, Edwards TE, Gupta A
Biometals 31 1081-1089 (2018)
PMID: 30311019

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 679 amino acids
Theoretical weight: 75.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 20-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand FE 2 x FE
Ligand CO3 1 x CO3
Ligand POP 1 x POP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 74.37Å b: 90.16Å c: 110.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.18 0.253
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases.
Kontoghiorghes et al. (2020)
2 more

1 mention without citation

Ferric pyrophosphate citrate: interactions with transferrin.
Pratt et al. (2018)