› 6csd

X-ray diffraction
2.39Å resolution

V308E mutant of cytochrome P450 2D6 complexed with prinomastat

Released:
DOI: 10.2210/pdb6csd/pdb
PDB entry 6csd coloured by chain, front view.
PDB entry 6csd coloured by chain, side view.
PDB entry 6csd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yang YT, Fujita K, Wang PF, Im SC, Pearl NM, Meagher J, Stuckey J, Waskell L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145367 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2D6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 479 amino acids
Theoretical weight: 53.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10635 (Residues: 34-497; Coverage: 93%)
Gene names: CYP2D6, CYP2DL1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

4 bound ligands:
Ligand HEM 2 x HEM
Ligand PN0 2 x PN0
Ligand CPS 2 x CPS
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21212
Unit cell:
a: 57.472Å b: 126.527Å c: 192.258Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.236
Expression system: Escherichia coli

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