› 6cmy

Solution NMR

Solution NMR Structure Determination of Mouse Melanoregulin

Released:
DOI: 10.2210/pdb6cmy/pdb
PDB entry 6cmy coloured by chain, ensemble of 20 models, front view.
PDB entry 6cmy coloured by chain, ensemble of 20 models, side view.
PDB entry 6cmy coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function.
Rout AK, Wu X, Starich MR, Strub MP, Hammer JA, Tjandra N
Structure 26 1373-1383.e4 (2018)
PMID: 30174147

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180073 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoregulin Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6NVG5 (Residues: 33-214; Coverage: 85%)
Gene names: Dsu, Gm974, Mreg, Wdt2
Sequence domains: Melanoregulin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 58%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Recent advances in understanding the molecular basis of melanogenesis in melanocytes.
Ohbayashi et al. (2020)
1 more

1 mention without citation

The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function.
Rout et al. (2018)