› 6c9a

Electron Microscopy
3.2Å resolution

Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state

Released:
DOI: 10.2210/pdb6c9a/pdb
PDB entry 6c9a coloured by chain, front view.
PDB entry 6c9a coloured by chain, side view.
PDB entry 6c9a coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature 556 130-134 (2018)
PMID: 29562233
Related structures: EMD-7435

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Two pore calcium channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 825 amino acids
Theoretical weight: 95.41 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9EQJ0 (Residues: 1-817; Coverage: 100%)
Gene names: Kiaa1169, Tpc1, Tpcn1
Sequence domains: Ion transport protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand EUJ 2 x EUJ
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-7435
Expression system: Homo sapiens

Quick links

Citations

40 review citations

Lysosomal Ion Channels as Decoders of Cellular Signals.
Li et al. (2019)
39 more

10 mentions without citation

Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.
Dickson et al. (2019)
9 more