› 6c6z

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230684 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 25.34 KDa
Source organism: Middle East respiratory syndrome-related coronavirus
Expression system: Homo sapiens
UniProt:
  • Canonical: K9N5Q8 (Residues: 367-589; Coverage: 17%)
Gene names: 3, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:
Antibody CDC2-C2 heavy chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 239 amino acids
Theoretical weight: 25.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody CDC2-C2 light chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 218 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 60.819Å b: 166.85Å c: 184.819Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.228
Expression system: Homo sapiens

Quick links

Citations

35 review citations

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans.
Sadarangani et al. (2021)
34 more

7 mentions without citation

Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain.
Zhou et al. (2019)
6 more