› 6c1k

X-ray diffraction
2.7Å resolution

HypoPP mutant with ligand1

Released:
DOI: 10.2210/pdb6c1k/pdb
PDB entry 6c1k coloured by chain, front view.
PDB entry 6c1k coloured by chain, side view.
PDB entry 6c1k coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Structural basis for gating pore current in periodic paralysis.
Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA
Nature 557 590-594 (2018)
PMID: 29769724

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 33 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein

Ligands and Environments

4 bound ligands:
Ligand GAI 2 x GAI
Ligand PX4 17 x PX4
Ligand NA 4 x NA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I222
Unit cell:
a: 126.394Å b: 126.235Å c: 191.525Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.246
Expression system: Trichoplusia ni

Quick links

Citations

12 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
11 more

4 mentions without citation

Recent advances in our understanding of the structure and function of more unusual cation channels.
Brown et al. (2019)
3 more