› 6brh

X-ray diffraction
3.4Å resolution

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

Released:
DOI: 10.2210/pdb6brh/pdb
PDB entry 6brh coloured by chain, front view.
PDB entry 6brh coloured by chain, side view.
PDB entry 6brh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Buzovetsky O, Tang C, Knecht KM, Antonucci JM, Wu L, Ji X, Xiong Y
Nat Commun 9 411 (2018)
PMID: 29379009

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 672 amino acids
Theoretical weight: 77.55 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q60710 (Residues: 1-658; Coverage: 100%)
Gene names: Mg21, Samhd1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand DGT 2 x DGT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21212
Unit cell:
a: 112.031Å b: 130.053Å c: 90.765Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.247
Expression system: Escherichia coli

Quick links

Citations

6 review citations

SAMHD1 Functions and Human Diseases.
Coggins et al. (2020)
5 more

1 mention without citation

The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Buzovetsky et al. (2018)