› 6bhs

X-ray diffraction
1.98Å resolution

HIV-1 CA hexamer in complex with IP6, hexagonal crystal form

Released:
DOI: 10.2210/pdb6bhs/pdb
PDB entry 6bhs coloured by chain, front view.
PDB entry 6bhs coloured by chain, side view.
PDB entry 6bhs coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Primary publication:
Inositol phosphates are assembly co-factors for HIV-1.
Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, Pornillos O, Vogt VM
Nature 560 509-512 (2018)
PMID: 30069050

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.46 KDa
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand IHP 1 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P6
Unit cell:
a: 90.649Å b: 90.649Å c: 56.614Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.236 0.284
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Restriction of HIV-1 and other retroviruses by TRIM5.
Ganser-Pornillos et al. (2019)
30 more

4 mentions without citation

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.
Obr et al. (2021)
3 more