› 6bhf

X-ray diffraction
2.09Å resolution

Crystal structure of the petidylprolyl cis,trans-isomerase from Helicobacter pylori

Released:
DOI: 10.2210/pdb6bhf/pdb
PDB entry 6bhf coloured by chain, front view.
PDB entry 6bhf coloured by chain, side view.
PDB entry 6bhf coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Primary publication:
Structural flexibility in the Helicobacter pylori peptidyl-prolyl cis,trans-isomerase HP0175 is achieved through an extension of the chaperone helices.
Yaseen A, Audette GF
J Struct Biol 204 261-269 (2018)
PMID: 30179659

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative peptidyl-prolyl cis-trans isomerase HP_0175 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.12 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P56112 (Residues: 1-299; Coverage: 100%)
Gene name: HP_0175
Sequence domains: PPIC-type PPIASE domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P3221
Unit cell:
a: 90.951Å b: 90.951Å c: 67.048Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.214 0.275
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Review: Pathogenesis of Helicobacter pylori infection.
Chmiela et al. (2019)
1 more