› 6atr

X-ray diffraction
1.29Å resolution

Crystal structure of hGSTA1-1 complexed with two GSH analogues in each subunit

Released:
DOI: 10.2210/pdb6atr/pdb
PDB entry 6atr coloured by chain, front view.
PDB entry 6atr coloured by chain, side view.
PDB entry 6atr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kumari V, Ji X

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 25.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08263 (Residues: 2-222; Coverage: 100%)
Gene name: GSTA1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSN 2 x GSN
2 bound ligands:
Ligand BWS 2 x BWS
Ligand EDO 14 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 100.163Å b: 94.487Å c: 51.782Å
α: 90° β: 92.65° γ: 90°
R-values:
R R work R free
0.168 0.168 0.182
Expression system: Escherichia coli BL21(DE3)

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