› 6agh

X-ray diffraction
2.74Å resolution

Crystal structure of EFHA1 in Apo-State

Released:
DOI: 10.2210/pdb6agh/pdb
PDB entry 6agh coloured by chain, front view.
PDB entry 6agh coloured by chain, side view.
PDB entry 6agh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter.
Xing Y, Wang M, Wang J, Nie Z, Wu G, Yang X, Shen Y
Cell Rep 26 1203-1212.e4 (2019)
PMID: 30699349

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uptake protein 2, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 39.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYU8 (Residues: 62-398; Coverage: 78%)
Gene names: EFHA1, MICU2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P1
Unit cell:
a: 44.712Å b: 63.199Å c: 66.115Å
α: 92.36° β: 101.75° γ: 96.74°
R-values:
R R work R free
0.219 0.213 0.272
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Mitochondrial calcium exchange in physiology and disease.
Garbincius et al. (2022)
8 more

2 mentions without citation

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Fan et al. (2020)
1 more