6aez

X-ray diffraction
1.63Å resolution

Crystal structure of human CCL5 trimer

Released:
Source organism: Homo sapiens
Primary publication:
Human CCL5 trimer: expression, purification and initial crystallographic studies.
Acta Crystallogr F Struct Biol Commun 74 82-85 (2018)
PMID: 29400316

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146623 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C-C motif chemokine 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 69 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13501 (Residues: 24-91; Coverage: 100%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
C-C motif chemokine 5 Chain: B
Molecule details ›
Chain: B
Length: 69 amino acids
Theoretical weight: 7.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13501 (Residues: 24-91; Coverage: 100%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P41212
Unit cell:
a: 56.556Å b: 56.556Å c: 154.103Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.228
Expression system: Escherichia coli