› 6aei

Electron Microscopy
2.89Å resolution

Cryo-EM structure of the receptor-activated TRPC5 ion channel

Released:
DOI: 10.2210/pdb6aei/pdb
PDB entry 6aei coloured by chain, front view.
PDB entry 6aei coloured by chain, side view.
PDB entry 6aei coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function.
Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J
Sci Adv 5 eaaw7935 (2019)
PMID: 31355338
Related structures: EMD-9615

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 765 amino acids
Theoretical weight: 88.9 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9QX29 (Residues: 1-765; Coverage: 79%)
Gene names: Trp5, Trpc5, Trrp5
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NA 5 x NA
Ligand Y01 4 x Y01
Ligand LPP 4 x LPP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-9615
Expression system: Spodoptera frugiperda

Quick links

Citations

18 review citations

TRPC channels: Structure, function, regulation and recent advances in small molecular probes.
Wang et al. (2020)
17 more

11 mentions without citation

What is new about mild temperature sensing? A review of recent findings.
García-Ávila et al. (2019)
10 more