› 6adh

X-ray diffraction
2.9Å resolution

STRUCTURE OF TRICLINIC TERNARY COMPLEX OF HORSE LIVER ALCOHOL DEHYDROGENASE AT 2.9 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb6adh/pdb
PDB entry 6adh coloured by chain, front view.
PDB entry 6adh coloured by chain, side view.
PDB entry 6adh coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.
Eklund H, Samma JP, Wallén L, Brändén CI, Akeson A, Jones TA
J Mol Biol 146 561-87 (1981)
PMID: 7024556

Function and Biology Details

Reaction catalysed: 
A primary alcohol + NAD(+) = an aldehyde + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132405 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alcohol dehydrogenase E chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 374 amino acids
Theoretical weight: 39.85 KDa
Source organism: Equus caballus
Expression system: Not provided
UniProt:
  • Canonical: P00327 (Residues: 2-375; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
2 bound ligands:
Ligand ZN 4 x ZN
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 52Å b: 44.6Å c: 94.4Å
α: 104.4° β: 101.9° γ: 70.7°
Expression system: Not provided

Quick links

Citations

11 review citations

The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.
Walker JE. (1992)
10 more

12 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
11 more