› 5zaz

Solution NMR

Solution structure of integrin b2 monomer tranmembrane domain in bicelle

Released:
DOI: 10.2210/pdb5zaz/pdb
PDB entry 5zaz coloured by chain, ensemble of 20 models, front view.
PDB entry 5zaz coloured by chain, ensemble of 20 models, side view.
PDB entry 5zaz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Intramembrane ionic protein-lipid interaction regulates integrin structure and function.
Guo J, Zhang Y, Li H, Chu H, Wang Q, Jiang S, Li Y, Shen H, Li G, Chen J, Xu C
PLoS Biol 16 e2006525 (2018)
PMID: 30427828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 5.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05107 (Residues: 689-739; Coverage: 7%)
Gene names: CD18, ITGB2, MFI7
Sequence domains: Integrin beta cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 98%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Computational Modeling of Realistic Cell Membranes.
Marrink et al. (2019)
2 more

3 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
2 more