› 5yxb

X-ray diffraction
2.95Å resolution

A ligand binding to FXR

Released:
DOI: 10.2210/pdb5yxb/pdb
PDB entry 5yxb coloured by chain, front view.
PDB entry 5yxb coloured by chain, side view.
PDB entry 5yxb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yi L, Yong L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RI1 (Residues: 258-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 741-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 93O 1 x 93O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P4222
Unit cell:
a: 86.399Å b: 86.399Å c: 75.106Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.246 0.282
Expression systems:
  • Escherichia coli
  • Not provided

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