› 5yk5

X-ray diffraction
2.03Å resolution

structure of the human Lamtor4-Lamtor5 complex

Released:
DOI: 10.2210/pdb5yk5/pdb
PDB entry 5yk5 coloured by chain, front view.
PDB entry 5yk5 coloured by chain, side view.
PDB entry 5yk5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
Mu Z, Wang L, Deng W, Wang J, Wu G
Cell Discov 3 17049 (2017)
PMID: 29285400

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128941 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ragulator complex protein LAMTOR4, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0VGL1 (Residues: 9-92; Coverage: 85%)
Gene names: C7orf59, LAMTOR4
Ragulator complex protein LAMTOR5 Chain: B
Molecule details ›
Chain: B
Length: 89 amino acids
Theoretical weight: 9.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43504 (Residues: 3-90; Coverage: 97%)
Gene names: HBXIP, LAMTOR5, XIP
Sequence domains: Ragulator complex protein LAMTOR5
Structure domains: Dynein light chain 2a, cytoplasmic
Ragulator complex protein LAMTOR4, N-terminally processed Chain: C
Molecule details ›
Chain: C
Length: 84 amino acids
Theoretical weight: 9.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0VGL1 (Residues: 9-91; Coverage: 84%)
Gene names: C7orf59, LAMTOR4
Ragulator complex protein LAMTOR5 Chain: D
Molecule details ›
Chain: D
Length: 86 amino acids
Theoretical weight: 9.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43504 (Residues: 4-89; Coverage: 95%)
Gene names: HBXIP, LAMTOR5, XIP
Sequence domains: Ragulator complex protein LAMTOR5
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P32
Unit cell:
a: 76.672Å b: 76.672Å c: 52.939Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.233 0.294
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Nutrient regulation of mTORC1 at a glance.
Condon et al. (2019)
9 more

2 mentions without citation

Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
Mu et al. (2017)
1 more