› 5xri

X-ray diffraction
1.68Å resolution

Galectin-10/Charcot-Leyden crystal protein-C29A crystal structure

Released:
DOI: 10.2210/pdb5xri/pdb
PDB entry 5xri coloured by chain, front view.
PDB entry 5xri coloured by chain, side view.
PDB entry 5xri coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding.
Su J, Gao J, Si Y, Cui L, Song C, Wang Y, Wu R, Tai G, Zhou Y
Glycobiology 28 159-168 (2018)
PMID: 29293962

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-10 Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05315 (Residues: 1-142; Coverage: 100%)
Gene names: CLC, LGALS10, LGALS10A
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P6522
Unit cell:
a: 48.937Å b: 48.937Å c: 258.665Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.183 0.204
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design.
Modenutti et al. (2019)
5 more