› 5xp5

X-ray diffraction
2.1Å resolution

C-Src in complex with ATP-Chf

Released:
DOI: 10.2210/pdb5xp5/pdb
PDB entry 5xp5 coloured by chain, front view.
PDB entry 5xp5 coloured by chain, side view.
PDB entry 5xp5 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.
Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C
J Am Chem Soc 139 7701-7704 (2017)
PMID: 28535041

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 8BU 2 x 8BU
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 42.288Å b: 63.687Å c: 73.815Å
α: 79.07° β: 89.23° γ: 89.24°
R-values:
R R work R free
0.219 0.218 0.246
Expression system: Escherichia coli K-12

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Citations

1 review citation

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors.
Dai et al. (2019)
6 other articles