› 5xfl

X-ray diffraction
2.45Å resolution

Crystal structure of the force-sensing device region of alpha N-catenin

Released:
DOI: 10.2210/pdb5xfl/pdb
PDB entry 5xfl coloured by chain, front view.
PDB entry 5xfl coloured by chain, side view.
PDB entry 5xfl coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The force-sensing device region of α-catenin is an intrinsically disordered segment in the absence of intramolecular stabilization of the autoinhibitory form.
Hirano Y, Amano Y, Yonemura S, Hakoshima T
Genes Cells 23 370-385 (2018)
PMID: 29542234

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin alpha-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 375 amino acids
Theoretical weight: 41.74 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q61301 (Residues: 260-632; Coverage: 39%)
Gene names: Catna2, Ctnna2
Sequence domains: Vinculin family
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 131.728Å b: 52.206Å c: 154.31Å
α: 90° β: 95.05° γ: 90°
R-values:
R R work R free
0.226 0.224 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 citation in other articles

An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex.
Bush et al. (2019)
7 more

3 mentions without citation

The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN.
Martín-Mora et al. (2019)
2 more