› 5wde

X-ray diffraction
1.85Å resolution

Crystal structure of the KIFC3 motor domain in complex with ADP

Released:
DOI: 10.2210/pdb5wde/pdb
PDB entry 5wde coloured by chain, front view.
PDB entry 5wde coloured by chain, side view.
PDB entry 5wde coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Park HW, Ma Z, Zhu H, Jiang S, Robinson RC, Endow SA
Sci Rep 7 15121 (2017)
PMID: 29123223

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIFC3 Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BVG8 (Residues: 443-770; Coverage: 39%)
Gene name: KIFC3
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand UNX 46 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: R32
Unit cell:
a: 187.608Å b: 187.608Å c: 151.363Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.199
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

Distinct retrograde microtubule motor sets drive early and late endosome transport.
Villari et al. (2020)
8 more

1 mention without citation

Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Park et al. (2017)