› 5vwc

X-ray diffraction
1.91Å resolution

Crystal structure of human Scribble PDZ1 domain

Released:
DOI: 10.2210/pdb5vwc/pdb
PDB entry 5vwc coloured by chain, front view.
PDB entry 5vwc coloured by chain, side view.
PDB entry 5vwc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.
Lim KYB, Gödde NJ, Humbert PO, Kvansakul M
J Biol Chem 292 20425-20436 (2017)
PMID: 29061852

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171945 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein scribble homolog Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 10.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q14160 (Residues: 725-815; Coverage: 6%)
Gene names: CRIB1, KIAA0147, LAP4, SCRB1, SCRIB, VARTUL
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 35.49Å b: 41.693Å c: 51.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.227
Expression system: Escherichia coli K-12

Quick links

Citations

4 review citations

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation.
Bonello et al. (2019)
3 more

4 mentions without citation

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
Caria et al. (2018)
3 more