5vlp

X-ray diffraction
2.9Å resolution

PCSK9 complex with LDLR antagonist peptide and Fab7G7

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-230549 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Fab7G7 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 24.12 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.66 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: A0A0U5BC76 (Residues: 21-234; Coverage: 100%)
Gene name: LC
Sequence domains:
Structure domains: Immunoglobulins
LDLR antagonist peptide Chain: Z
Molecule details ›
Chain: Z
Length: 17 amino acids
Theoretical weight: 1.93 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: I222
Unit cell:
a: 110.865Å b: 142.168Å c: 239.365Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.209
Expression systems:
  • Cricetulus griseus
  • Mus musculus
  • Not provided