› 5uv6

X-ray diffraction
2.65Å resolution

Crystal structure of human Opioid Binding Protein/Cell Adhesion Molecule Like (OPCML)

Released:
DOI: 10.2210/pdb5uv6/pdb
PDB entry 5uv6 coloured by chain, front view.
PDB entry 5uv6 coloured by chain, side view.
PDB entry 5uv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.
Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver GC, Von Arx C, Mura M, Marinho AT, Lu H, Morecroft EVN, Karali E, Chayen NE, Tate EW, Jurewicz M, Stern LJ, Recchi C, Gabra H
Nat Commun 10 3134 (2019)
PMID: 31316070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Opioid-binding protein/cell adhesion molecule Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 31.63 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q14982 (Residues: 36-316; Coverage: 88%)
Gene names: IGLON1, OBCAM, OPCML
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P41212
Unit cell:
a: 93.564Å b: 93.564Å c: 262.158Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.285 0.284 0.3
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.
Antony et al. (2021)
5 other articles

3 mentions without citation

Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
Venkannagari et al. (2020)
2 more