› 5uoj

X-ray diffraction
2.1Å resolution

THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb5uoj/pdb
PDB entry 5uoj coloured by chain, front view.
PDB entry 5uoj coloured by chain, side view.
PDB entry 5uoj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Wang Z, Harkins PC, Ulevitch RJ, Han J, Cobb MH, Goldsmith EJ
Proc Natl Acad Sci U S A 94 2327-32 (1997)
PMID: 9122194

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 43.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 45.756Å b: 84.928Å c: 123.911Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.154 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
Roux et al. (2004)
38 more

8 mentions without citation

Essential site scanning analysis: A new approach for detecting sites that modulate the dispersion of protein global motions.
Kaynak et al. (2020)
7 more