5tzn

X-ray diffraction
2.6Å resolution

Structure of the viral immunoevasin m12 (Smith) bound to the natural killer cell receptor NKR-P1B (B6)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-112577 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Killer cell lectin-like receptor subfamily B member 1B allele B Chains: A, W
Molecule details ›
Chains: A, W
Length: 137 amino acids
Theoretical weight: 15.63 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99JB4 (Residues: 89-215; Coverage: 57%)
Gene names: Klrb1b, Klrb1d, Ly55d, Nkrp1b, Nkrp1d
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A
Glycoprotein family protein m12 Chains: F, G
Molecule details ›
Chains: F, G
Length: 190 amino acids
Theoretical weight: 21.22 KDa
Source organism: Murid betaherpesvirus 1
Expression system: Trichoplusia ni
UniProt:
  • Canonical: D3XDJ6 (Residues: 61-240; Coverage: 66%)
Gene name: m12
Sequence domains: Immune evasion protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 165.276Å b: 61.912Å c: 66.159Å
α: 90° β: 101.92° γ: 90°
R-values:
R R work R free
0.207 0.204 0.252
Expression systems:
  • Homo sapiens
  • Trichoplusia ni