› 5tin

X-ray diffraction
2.61Å resolution

Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607

Released:
DOI: 10.2210/pdb5tin/pdb
PDB entry 5tin coloured by chain, front view.
PDB entry 5tin coloured by chain, side view.
PDB entry 5tin coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shaffer PL, Huang X, Chen H

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130887 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine receptor subunit alpha-3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 362 amino acids
Theoretical weight: 41.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75311 (Residues: 34-342, 419-460; Coverage: 81%)
Gene name: GLRA3
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 7C6 5 x 7C6
Ligand GLY 5 x GLY
Ligand ZN 5 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 136.301Å b: 136.787Å c: 192.495Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.214
Expression system: Spodoptera frugiperda

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