› 5qrj

X-ray diffraction
1.81Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z416341642

Released:
DOI: 10.2210/pdb5qrj/pdb
PDB entry 5qrj coloured by chain, front view.
PDB entry 5qrj coloured by chain, side view.
PDB entry 5qrj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Fernandez-Cid A, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

2 bound ligands:
Ligand CD 5 x CD
Ligand NWP 1 x NWP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P4122
Unit cell:
a: 60.104Å b: 60.104Å c: 109.812Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.273
Expression system: Escherichia coli

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