› 5qqu

X-ray diffraction
1.55Å resolution

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1348371854

Released:
DOI: 10.2210/pdb5qqu/pdb
PDB entry 5qqu coloured by chain, front view.
PDB entry 5qqu coloured by chain, side view.
PDB entry 5qqu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bezerra GA, Foster W, Bailey H, Shrestha L, Krojer T, Talon R, Brandao-Neto J, Douangamath A, Nicola BB, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Brennan PE, Yue WW

Function and Biology Details

Reaction catalysed: 
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-aminolevulinate synthase, erythroid-specific, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22557 (Residues: 143-578; Coverage: 74%)
Gene names: ALAS2, ALASE, ASB
Sequence domains: Aminotransferase class I and II

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
1 bound ligand:
Ligand NTG 3 x NTG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 126.098Å b: 108.53Å c: 75.721Å
α: 90° β: 109.03° γ: 90°
R-values:
R R work R free
0.212 0.211 0.235
Expression system: Spodoptera frugiperda

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