› 5of9

X-ray diffraction
1.81Å resolution

Crystal structure of human MORC2 (residues 1-603)

Released:
DOI: 10.2210/pdb5of9/pdb
PDB entry 5of9 coloured by chain, front view.
PDB entry 5of9 coloured by chain, side view.
PDB entry 5of9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y
Nat Commun 9 651 (2018)
PMID: 29440755

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase MORC2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 606 amino acids
Theoretical weight: 70.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 2 RZ-2014
UniProt:
  • Canonical: Q9Y6X9 (Residues: 1-603; Coverage: 58%)
Gene names: KIAA0852, MORC2, ZCWCC1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P21
Unit cell:
a: 66.17Å b: 127.93Å c: 80.19Å
α: 90° β: 101.22° γ: 90°
R-values:
R R work R free
0.162 0.161 0.188
Expression system: Spodoptera aff. frugiperda 2 RZ-2014

Quick links

Citations

14 review citations

Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance.
Padeken et al. (2022)
13 more

2 mentions without citation

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Douse et al. (2018)
1 more