› 5o9y

X-ray diffraction
1.57Å resolution

Crystal structure of ScGas2 in complex with compound 11

Released:
DOI: 10.2210/pdb5o9y/pdb
PDB entry 5o9y coloured by chain, front view.
PDB entry 5o9y coloured by chain, side view.
PDB entry 5o9y coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Inhibitors against Fungal Cell Wall Remodeling Enzymes.
Delso I, Valero-Gonzalez J, Gomollón-Bel F, Castro-López J, Fang W, Navratilova I, van Aalten DMF, Tejero T, Merino P, Hurtado-Guerrero R
ChemMedChem 13 128-132 (2018)
PMID: 29164827

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170293 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1,3-beta-glucanosyltransferase GAS2 Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 62.43 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q06135 (Residues: 1-555; Coverage: 100%)
Gene names: GAS2, L8300.5, YLR343W
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 9PN 1 x 9PN
Ligand EDO 9 x EDO
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 49.92Å b: 70.38Å c: 150.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.233
Expression system: Komagataella pastoris

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Citations

3 citation in other articles

Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls.
Vogt et al. (2020)
2 more