› 5npq

X-ray diffraction
2.37Å resolution

Human N-myristoyltransferase 1 (MNT1) with Myristoyl-CoA analogue X10 bound

Released:
DOI: 10.2210/pdb5npq/pdb
PDB entry 5npq coloured by chain, front view.
PDB entry 5npq coloured by chain, side view.
PDB entry 5npq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shen M, Perez-Dorado I, Fedoryshchak R, Tate EW

Function and Biology Details

Reaction catalysed: 
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 45.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30419 (Residues: 109-496; Coverage: 78%)
Gene names: NMT, NMT1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GOL 4 x GOL
Ligand 94Q 2 x 94Q
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 79.972Å b: 177.454Å c: 58.244Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.261
Expression system: Escherichia coli BL21(DE3)

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