› 5nir

X-ray diffraction
1.74Å resolution

Crystal structure of collagen 2A vWC domain

Released:
DOI: 10.2210/pdb5nir/pdb
PDB entry 5nir coloured by chain, front view.
PDB entry 5nir coloured by chain, side view.
PDB entry 5nir coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.
Xu ER, Blythe EE, Fischer G, Hyvönen M
J Biol Chem 292 12516-12527 (2017)
PMID: 28584056

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagen alpha-1(II) chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 74 amino acids
Theoretical weight: 7.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02458 (Residues: 29-98; Coverage: 5%)
Gene name: COL2A1
Sequence domains: von Willebrand factor type C domain

Ligands and Environments

4 bound ligands:
Ligand EDO 8 x EDO
Ligand PEG 7 x PEG
Ligand PG4 6 x PG4
Ligand P33 1 x P33
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 31.93Å b: 60.16Å c: 86.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Structural biology of the TGFβ family.
Goebel et al. (2019)
7 more

5 mentions without citation

Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery.
Chen et al. (2020)
4 more