› 5n18

X-ray diffraction
1.45Å resolution

Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2)

Released:
DOI: 10.2210/pdb5n18/pdb
PDB entry 5n18 coloured by chain, front view.
PDB entry 5n18 coloured by chain, side view.
PDB entry 5n18 coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C
Nat Commun 8 15482 (2017)
PMID: 28516956

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.63 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5A4W8 (Residues: 386-491; Coverage: 15%)
Gene names: BDF1, CAALFM_C500200CA, CaO19.8593, CaO19.978
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand 8HZ 1 x 8HZ
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 46.484Å b: 35.997Å c: 64.495Å
α: 90° β: 107.61° γ: 90°
R-values:
R R work R free
0.161 0.159 0.198
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The BET family in immunity and disease.
Wang et al. (2021)
3 more

3 mentions without citation

The Groebke-Blackburn-Bienaymé Reaction.
Boltjes et al. (2019)
2 more