› 5mw2

X-ray diffraction
2.35Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand U52 1 x U52
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 31.367Å b: 72.657Å c: 54.883Å
α: 90° β: 105.87° γ: 90°
R-values:
R R work R free
0.249 0.247 0.283

Quick links

Citations

28 review citations

Advances in targeting 'undruggable' transcription factors with small molecules.
Henley et al. (2021)
27 more

5 mentions without citation

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
Aatkar et al. (2023)
4 more