› 5mvz

X-ray diffraction
2.15Å resolution

Fab 4AB007 bound to Interleukin-1-beta

Released:
DOI: 10.2210/pdb5mvz/pdb
PDB entry 5mvz coloured by chain, front view.
PDB entry 5mvz coloured by chain, side view.
PDB entry 5mvz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stark W, Seibert V

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208443 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab 4AB007 H-chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 240 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fab 4AB007 L-chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 249 amino acids
Theoretical weight: 27.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Interleukin-1 beta Chains: U, V
Molecule details ›
Chains: U, V
Length: 177 amino acids
Theoretical weight: 20.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01584 (Residues: 117-269; Coverage: 57%)
Gene names: IL1B, IL1F2
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand GOL 8 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: C2221
Unit cell:
a: 111.041Å b: 158.385Å c: 153.437Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.219 0.281
Expression system: Homo sapiens

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