› 5ms7

X-ray diffraction
2.8Å resolution

Crystal structure of the legionella pneumophila effector protein RavZ_20-502

Released:
DOI: 10.2210/pdb5ms7/pdb
PDB entry 5ms7 coloured by chain, front view.
PDB entry 5ms7 coloured by chain, side view.
PDB entry 5ms7 coloured by chain, top view.
Source organism: Legionella pneumophila subsp. pneumophila ATCC 33215
Primary publication:
Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Yang A, Pantoom S, Wu YW
Elife 6 (2017)
PMID: 28395732

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine protease RavZ Chain: A
Molecule details ›
Chain: A
Length: 485 amino acids
Theoretical weight: 54.29 KDa
Source organism: Legionella pneumophila subsp. pneumophila ATCC 33215
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5ZUV9 (Residues: 20-502; Coverage: 96%)
Gene names: lpg1683, ravZ

Ligands and Environments

2 bound ligands:
Ligand BA 2 x BA
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I422
Unit cell:
a: 222.77Å b: 222.77Å c: 72.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.254
Expression system: Escherichia coli BL21

Quick links

Citations

19 review citations

Autophagy in major human diseases.
Klionsky et al. (2021)
18 more

2 mentions without citation

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Yang et al. (2017)
1 more