› 5maf

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maternal embryonic leucine zipper kinase Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 40.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14680 (Residues: 2-340; Coverage: 52%)
Gene names: KIAA0175, MELK
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand DMS 1 x DMS
Ligand CL 1 x CL
Ligand XIN 1 x XIN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 59.913Å b: 63.713Å c: 91.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.259
Expression system: Spodoptera frugiperda

Quick links

Citations

66 review citations

Regulation and Function of the PD-L1 Checkpoint.
Sun et al. (2018)
65 more

2 mentions without citation

The target landscape of clinical kinase drugs.
Klaeger et al. (2017)
1 more