› 5lxg

X-ray diffraction
2.73Å resolution

Revised crystal structure of the human adiponectin receptor 1 in an open conformation

Released:
DOI: 10.2210/pdb5lxg/pdb
PDB entry 5lxg coloured by chain, front view.
PDB entry 5lxg coloured by chain, side view.
PDB entry 5lxg coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S
Nature 544 120-123 (2017)
PMID: 28329765

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212679 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adiponectin receptor protein 1 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96A54 (Residues: 89-375; Coverage: 77%)
Gene names: ADIPOR1, CGI-45, PAQR1, TESBP1A
Sequence domains: Haemolysin-III related
V REGION HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 119 amino acids
Theoretical weight: 13.16 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
V REGION LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.65 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 92.31Å b: 194.11Å c: 74.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.234
Expression systems:
  • Trichoplusia ni
  • Escherichia coli

Quick links

Citations

51 review citations

Sphingolipids and their metabolism in physiology and disease.
Hannun et al. (2018)
50 more

10 mentions without citation

Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks et al. (2017)
9 more