› 5lq2

X-ray diffraction
3.4Å resolution

Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution

Released:
DOI: 10.2210/pdb5lq2/pdb
PDB entry 5lq2 coloured by chain, front view.
PDB entry 5lq2 coloured by chain, side view.
PDB entry 5lq2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
Ecsédi P, Kiss B, Gógl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vértessy B, Jeszenői N, Hetényi C, Schlosser G, Katona G, Nyitray L
Structure 25 1195-1207.e5 (2017)
PMID: 28669632

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 38.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07355 (Residues: 2-339; Coverage: 100%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 10 x CA
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 61.37Å b: 99.2Å c: 173.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.234
Expression system: Escherichia coli

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Citations

7 review citations

Advances in cancer treatment: a new therapeutic target, Annexin A2.
Li et al. (2021)
6 more